RNA Editing (Methods in Enzymology, Vol 424)
Publisher: Academic Press
Number Of Pages: 560
Publication Date: 2007-08-06
Sales Rank: 263887
ISBN / ASIN: 0123739225
EAN: 9780123739223
Binding: Hardcover
Manufacturer: Academic Press
Studio: Academic Press
RNA processing plays a critical role in realizing the full potential of a given genome. One means of achieving protein diversity is through RNA editing. A diverse array of editing events has been characterized, affecting gene expression in organisms from viruses and single cell parasites to humans and plants. The variety of editing mechanisms has required the development of many different experimental approaches, many of which are likely to be broadly applicable, particularly given the interplay between editing and other cellular processes, including transcription, splicing, and RNA silencing. This volume not only covers most of the principal methods employed in the field, but also offers innovative solutions to the significant challenges posed by these experimental systems.
* Presents newly developed methods
* Covers topics ranging from biochemistry to bioinformatics
* Includes innovative solutions to potential problems
http://rapidshare.com/files/58917190/MenzaREdit.rar
RNA Modification (Methods in Enzymology, Vol 425)
Publisher: Academic Press
Number Of Pages: 480
Publication Date: 2007-08-06
Sales Rank: 923856
ISBN / ASIN: 0123741556
EAN: 9780123741554
Binding: Hardcover
Manufacturer: Academic Press
Studio: Academic Press
The presence of modified nucleotides in cellular RNAs has been known for decades and over 100 distinct RNA modifications have been characterized to date. While the exact role of many of these modifications is still unclear, many are highly conserved across evolution and most contribute to the overall fitness of the organism. In recent years, new methods and bioinformatics approaches have been developed for the dissection of modification pathways and functions. These methods intersect a number of related fields, ranging from RNA processing to comparative genomics and systems biology. In addition, many of the techniques described in this volume have broad applicability, particularly in regards to the isolation, characterization, and reconstitution of ribonucleoprotein complexes, expanding the experimental repertoire available to all RNA researchers.
http://rapidshare.com/files/58917530/MenzaRMod.rar
Integrins (Methods in Enzymology, Vol 426)
Publisher: Academic Press
Number Of Pages: 500
Publication Date: 2007-08-27
Sales Rank: 1974768
ISBN / ASIN: 0123739241
EAN: 9780123739247
Binding: Hardcover
Manufacturer: Academic Press
Studio: Academic Press
An integrin, or integrin receptor, is an integral membrane protein in the plasma membrane of cells. It plays a role in the attachment of a cell to the extracellular matrix (ECM) and to other cells, and in signal transduction from the ECM to the cell. There are many types of integrin, and many cells have multiple types on their surface. Integrins are of vital importance to all metazoans, from humans to sponges. This volume in Methods in Enzymology presents methods for studying integrins.
http://rapidshare.com/files/58916058/MenzaInteg.rar
MicroRNA Methods (Methods in Enzymology, Vol 427)
Publisher: Academic Press
Number Of Pages: 304
Publication Date: 2007-09-04
Sales Rank: 1007488
ISBN / ASIN: 0123739179
EAN: 9780123739179
Binding: Hardcover
Manufacturer: Academic Press
Studio: Academic Press
MicroRNAs (miRNA) are tiny bits of genetic material that were unknown nearly 10 years ago but now represent an exciting field of study in biology. Upon their discovery, researchers revealed for the first time a new mechanism by which microRNA can stop the function of messenger RNA (mRNA) by literally cutting it in half, interfering with the normal function of specific messenger RNAs in gene expression.
This "expression" of genes that code for essential proteins is essentially what controls whether a cell turns into a liver, lung, or brain cell, for example. Understanding what activates this process or stops it is a key to understanding the biological process and builds a foundation for advances in medicine and other fields. This volume in Methods in Enzymology presents valuable methods for studying MicroRNA, with three sections covering identification of MicroRNAs and their targets; Micro RNA expression, maturation and functional analysis; and MicroRNAs and disease.
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